GOUTYLESS 500MG 30 TAB; colchicine, probenecid, antigout agents .

ACTIVE-INGREDIENT OF GOUTYLESS 500MG 30 TAB

Each tablet for oral administration contains: Active ingredients: 500 mg of Probenecid and 0.5 mg of Colchicine.

INDICATION OF GOUTYLESS 500MG 30 TAB

For the treatment of chronic gouty arthritis when complicated by frequent, recurrent acute attacks of gout.

DOSAGE OF GOUTYLESS 500MG 30 TAB

Follow all directions given to you by your pharmacist or doctor carefully . They may differ from the information contained in this leaflet

Ask your pharmacist or doctor for help if you do not understand the instructions on the box .

The recommended dose is : –

Therapy with Probenecid and Colchicine should not be started until an acute gouty attack has studied. However, if an acute attack is precipitated during therapy, Goutyless may be continued without changing the dosage, an additional colchicine or other appropriate therapy should be given to control the acute attack. The recommended adult dosage is 1 tablet of Probenecid and Colchicine daily for one week, followed by 1 tablet twice a day thereafter. Some degree of renal impairmentmay be present in patients with gout. A daily dosage of 2 tablets may be adequate. However, if necessary, the daily dosage may be increased by 1 tablet every four weeks within tolerance ( and usually not above 4 tablets per day) if symptoms of gouty arthritis are not controlled or the 24 hour uric acid excretion is not above 700 mg. As noted, Probenecid may not be effective in chronic renal insufficiency particularly when the glomerular filteration rate is 30 ml/minute or less. Gastric intolerance may be indicative of overdosage, and may be corrected by decreasing the dosage. As uric acid tends to crystalize out of an acid urine, a liberal fluid intake is recommended, as well as sufficient sodium bicarbonate ( 3 to 7.5 g daily) or potassium citrate (7.5 g daily) to maintain an alkaline urine. Alkalization of the urine is recommended until the serum urate level returns to normal limits and tophaceous deposits disappear, i.e., during the period when urinary excretion of uric acid is at a high level. Thereafter, alkalization of the urine and the usual restriction of purine-producing foods may be somewhat relaxed. Probenecid and Colchicine ( or probenecid) should be continued at the dosage that will maintain normal serum urate levels. When acute attacks have been absent for six months or more and serum urate levels remain within normal limits, the daily dosage of Goutyless may be decreased by 1 tablet every six months. The maintenance dosage should not be reduced ro the point where serum urate levels tend to rise.

OVER-DOSAGE OF GOUTYLESS 500MG 30 TAB

CONTRA-INDICATION OF GOUTYLESS 500MG 30 TAB

Hypersensitivity to this product or to probenecid or colchicine. Goutyless tablets are contraindicated in children under 2 years of age. Not recommended in persons with known blood dyscarasias or uric acid kidney stones. Therapy with Goutyless should not be started until an acute gouty attack has subsided.

STORAGE OF GOUTYLESS 500MG 30 TAB

Store at temperature not exceeding 30°C, in dry place. Keep out of reach of children.
PACK OF GOUTYLESS 500MG 30 TAB
Carton box contains 1 or 2 or 3 ( Opaque P.V.C / Alum. ) strips each of 10 tablets + leaflet.
GOUTYLESS 500MG 30 TAB MANUFACTURED BY
OCTOBER PHARMA S.A.E. 6 October City – EGYPT.

https://www.webmd.com/drugs/2/drug-8697/probenecid-oral/details

https://gardeniapharmacies.com/category/medicine-2/