Active management of the third stage of labor (as a means to promote separation of the placenta and to reduce blood loss). Treatment of uterine atony/hemorrhage occuring during and after the third stage of labor, in association with Cesarean section or following abortion. Treatment of subinvolution of the uterus, lochiometra, puerperal bleeding.

DOSAGE OF METHERGIN 200 MCG 5 AMP 1 ML

Follow all directions given to you by your pharmacist or doctor carefully . They may differ from the information contained in this leaflet

Ask your pharmacist or doctor for help if you do not understand the instructions on the box .

The recommended dose is : –

Active management of the third stage of labor: Intramuscular injection (i.m.) is the recommended route of administration. When administered intravenously (i.v.) the dose must be administered slowly over a period of no less than 60 seconds. The recommended dosage of Methergin is : 1 ml (0.2 mg) i.m. or 0.5 to 1 mL (0.1 to 0.2 mg ) by slow i.v. administration following delivery of the anterior shoulder on at the latest, immediately after delivery of the child. Expulsion of the placenta, usually separated by the first strong contraction following Methergin, should be manually assisted by applying fundal pressure. For delivery under general anthesia, the recommended dose is 1 mL (0.2 mg ) by slow i.v. injection. Treatment of uterine atony/hemorrhage: I.m injection is the recommended route of administration . When administered intravenously (i.v.) the dose must be administered slowly over a period of no less than 60 seconds. The recommended dosage of Methergin is : 1 ml (0.2 mg) i.m. or 0.5 to 1 mL (0.1 to 0.2 mg ) by slow i.v. administration. The dose may be repeated every 2 to 4 hours, if necessary, up to five doses within 24 hours. Treatment of subinvolution of the uterus, lochiometra, puerperal bleeding: The recommended dosage of Methergin is : 1 to 2 tablets (0.125 to 0.25 mg ) orally, or 0.5 to 1 mL (0.1 to 0.2 mg ) s.c. or i.m., up to 3 times daily and usually for up to 5 days. Special populations: Renal impairment / Hepatic impairment: Caution should be exercised in the presence of impaired hepatic or renal function.

OVER-DOSAGE OF METHERGIN 200 MCG 5 AMP 1 ML

Nausea; vomiting; hypertension or hypotension; numbness; tingling and pain in the extremities; respiratory depression; convulsions; coma. Treatment: Elimination of orally ingested drug by administration of high doses of activated charcoal. Symptomatic treatment under close monitoring of the cardiovascular and the respiratory system. If sedation is required, benzodiazepines may be used. In case of severe arteriospasm, vasodilators should be administered, e.g. sodium nitroprusside, phentolamine or dihydralazine. In the event of coronary constriction, appropriate anti-anginal treatment should be provided (e.g. nitrates). Medication errors: Accidental administration to the newborn infant has been reported. In these accidental neonatal overdosage cases, symptoms such as respiratory depression, convulsions, cyanosis, oliguria, have been reported. Furthermore. Encephalopathy has been reported in infants presenting with signs and symptoms such as irritability, agitation and lethargy. Treatment should be symptomatic ; in severe cases respiratory and cardiovascular supports have been required. Fatal cases have been reported in the absence of adequate treatment.

CONTRA-INDICATION OF METHERGIN 200 MCG 5 AMP 1 ML

Pregnancy; First stage of labor; second stage of labor before delivery of the anterior shoulder (Methergin must not be used for induction or enhancement of labor); Severe hypertension; Pre-eclampsia; Occlusive vascular disease (including ischemic heart disease); Sepsis; Known hypersensitivity to methylergometrine , to other ergot alkaloids or to any excipients of Methergin.

STORAGE OF METHERGIN 200 MCG 5 AMP 1 ML

Methergin solution for injection: protect from light; store in a refrigerator (2-8 °C); protect from freezing; the ampoules may be stored for 14 days out of a refrigerator but not above 25 °C. Methergin should not be used after the date marked “EXP” on the pack. Methergin must be kept out of the sight and reach of children.
PACK OF METHERGIN 200 MCG 5 AMP 1 ML
5 ampoules.
METHERGIN 200 MCG 5 AMP 1 ML MANUFACTURED BY
NOVARTIS PHARMA S.A.E.

https://www.mayoclinic.org/drugs-supplements/methylergonovine-injection-route/description/drg-20075681#:~:text=Methylergonovine%20injection%20is%20used%20to,prevents%20bleeding%20after%20giving%20birth.

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